Getting My ceesdekker To Work
Getting My ceesdekker To Work
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Working with solitary-molecule optical and AFM imaging and force-spectroscopy methods, we seek out to unravel the mechanistic aspects of the composition and dynamics of chromosomes. Our investigation interests include:
Reconstitution of ultrawide DNA origami pores in liposomes for transmembrane transport of macromolecules
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Non-equilibrium folding of person DNA molecules recaptured as much as 1000 times in a solid point out nanopore
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Our investigation ranges through the biophysics of DNA to artificial cells and over and above. Remember to have a look under on the spectrum of our existing assignments.
All parameters have been the exact same for every panel in this video, except for the Preliminary placement in the 6hb rod (demonstrated in blue) within the nanopore. Simulations that terminated early resulting from translocation of your rod through the pore are marked by a grey background.
Dynamic ParB–DNA interactions initiate and retain a partition condensate for bacterial chromosome segregation
In 1993, to be a young and eager affiliate professor at Delft College of Technologies, I had to begin with concentrated the study initiatives of my team on measuring the electrical conductance of a single conducting-polymer molecule. Inside of two several years, we experienced created a device where only one wire of a phthalocyaninepolysiloxane polymer was connected amongst two intently spaced metallic nanoelectrodes.
There was a single dilemma nevertheless — we didn't notice any measurable electrical conduction from The one polymer molecules. We concluded that at The one-molecule level, conducting polymers were really not this sort of wonderful conductors, which was relatively disappointing. We Consequently broadened our view to test to find more promising molecules.
An built-in microfluidic System for quantifying drug permeation cees dekker across biomimetic vesicle membranes
Quite a few new phenomena have been found, and he and his investigate group established a number one place During this discipline of study. Dekker and his exploration group learned new physics of nanotubes along with explored the feasibility of molecular electronics. In 1998, they were being the primary to build a transistor based upon just one nanotube molecule.
For example, we think about the nucleopore intricate, a gateway among the cell nucleus as well as cytoplasm. This is an extremely difficult method and therefore tricky to review within a cell, so we use biomimetics. We reconstruct holes after which you can insert specific factors of the nucleopore advanced to review transportation by way of it at the single-molecule amount.’
Dekker heeft fundamentele ontdekkingen gedaan op het gebied van koolstof nanobuisjes. Mede vanwege deze werkzaamheden is hij al jaren de meest geciteerde fysicus in Nederland. Tegenwoordig onderzoekt hij achieved enkel-molecuultechnieken de biofysica van moleculen in de biologische cel. Dekker is naast zijn wetenschappelijk werk ook bekend vanwege zijn belangstelling voor de relatie tussen geloof en wetenschap en de discussie rond intelligent layout in 2005. (nl)